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Wednesday 02 Sep 2020
Humoral Immune Response to SARS-CoV-2 in Iceland.
Antiviral antibodies against SARS-CoV-2 did not decline within 4 months after diagnosis. We estimate that the risk of death from infection was 0.3% and that 44% of persons infected with SARS-CoV-2 in Iceland were not diagnosed by qPCR.
Original Article from The New England Journal of Medicine — Humoral Immune Response to SARS-CoV-2 in Iceland
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Tuesday 01 Sep 2020
A very useful educational collection of videos and webinars on COVID-19 from the ERS learning resources
Thank you Stelios Loukides and Pascal Kurosinski for the opportunity to share some views on "Telemedicine and e-medicine during a pandemic"
The ERS-education website provides centralised access to all educational material produced by the European Respiratory Society. It is the world’s largest CME collection for lung diseases and treatment offering high quality e-learning and teaching resources for respiratory specialists. This distanc...
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Monday 31 Aug 2020
Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset.
A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients.
Background Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated. Method Serial sera of 80 patient...
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Monday 31 Aug 2020
*Is COPD a risk factor for COVID-19?
*Why COPD patients appear to suffer worse outcomes upon contracting COVID-19?
*The usual algorithms of pharmaceutical management in COPD during pandemic still apply?
Directions for COVID-19 and COPD research can be best clarified by developing standards for transparent data reporting across the globe and harnessing the power of international networks that can quickly collate the data of COVID-19 COPD patients.
As of 11 July, 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic has infected over 12.7 million people around the world and caused more than 560,000 deaths [1]. Given the devastating impact that COVID-19 can...
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Monday 31 Aug 2020
A very interesting editorial.
“It is the long history of humankind (and animal kind, too) that those who learned to collaborate and improvise most effectively have prevailed.” — Charles Darwin
We frame the world, which then frames all our seeing, thinking and doing [1]. This is true individually, professionally and at the level of all our institutions. It is a perpetual work in progress that occasionally undergoes a single seismic shift. This is the situation that the world is currently e...
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Monday 31 Aug 2020
Fungal sensitisation is prevalent in COPD and associates with frequent representing a potential treatable trait.
Introduction Allergic sensitisation to fungi such as Aspergillus are associated to poor clinical outcomes in asthma, bronchiectasis and cystic fibrosis; however, clinical relevance in COPD remains unclear. Methods Patients with stable COPD (n=446) and nondiseased controls (n=51) were prospectively r...
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Monday 31 Aug 2020
Did you post an answer to the Wednesday Checkup? The correct answer is:
B. Bolus with 30 mL/kg normal saline
This patient has developed septic shock. Patients with sepsis have a high mortality rate when they develop hypotension which causes vital organ dysfunction. To maintain adequate organ perfusion, she should receive at least 30 cc/Kg of IVF within three hours of presentation with a goal MAP of 65mmHg (choice B is correct). The use of IV fluid in the resuscitation of patients is a cornerstone of therapy, and expert consensus recommends initial therapy with IVF before starting vasopressors (Choice A is incorrect). Corticosteroids should not be started before fluids and vasopressors (choice C is incorrect). Corticosteroids may decrease the duration of shock after the above therapies are implemented, but have not been shown to provide a mortality benefit. Choice D is incorrect because she has no evidence of bleeding, and therefore does not require blood transfusion at this time.
- Rivers, E, Nguyen B, Havstad S et al. Early Goal Directed therapy in the treatment of severe sepsis and septic shock. NEJM 2001; 345: 1368-1377.
- Rhodes, A., et al., Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med, 2017.
- Sprung CL, Annane D, Keh D, et al; CORTICUS Study Group: Hydrocortisone therapy for patients with septic shock. N Engl Med 2008; 358:111–124
- The ProCESS Investigators. A Randomized trial of protocol-based care for early septic shock. NEJM 2014; 370: 1683-1692.
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Sunday 30 Aug 2020
COVID19 pneumonia can be life-threatening. Given the unprecedented burden placed on ICU resources by the epidemic, avoiding intubation is a major issue. This study suggests that CPAP can achieve this objective. buff.ly/3lCeMw7
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause severe pneumonia requiring invasive mechanical ventilation [1], in the context of atypical acute respiratory distress syndrome (ARDS) [2]. The magnitude of the epidemic places an unprecedented pressure on intensive care units (IC...
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Sunday 30 Aug 2020
Single-Session Bronchial Thermoplasty Guided by 129Xe Magnetic Resonance Imaging. A Pilot Randomized Controlled Clinical Trial | American Journal of Respiratory and Critical Care Medicine
Rationale: Adverse events have limited the use of bronchial thermoplasty (BT) in severe asthma.Objectives: We sought to evaluate the effectiveness and safety of using 129Xe magnetic resonance imagi...
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Sunday 30 Aug 2020
Radiology–Pathology Correlation Demonstrating Organizing Pneumonia in a Patient Who Recovered from COVID-19
The few pathological analyses of coronavirus disease (COVID-19) pneumonia to date, mostly from autopsy studies, report diffuse alveolar damage or acute fibrinous and organizing pneumonia (1–3). In contrast, computed tomographic (CT) imaging from numerous patients with COVID-19 includes features mo...
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Saturday 29 Aug 2020
Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2
Saliva specimens collected by the patients were as good as (and sometimes better) compare with nasopharyngeal swab specimens (collected by healthcare workers) with respect to sensitivity in detection of SARS-CoV-2.
The results of this analysis may facilitate the mass screening for SARS-CoV-2 as well as the proper diagnosis of patients.
Correspondence from The New England Journal of Medicine — Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2
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Friday 28 Aug 2020
Do not miss our Opening session on Friday, September 18th 2020 @ 08:00 am LungCancer Chaired by M.Gaga (GR), T. Kontakiotis (GR), I. Dimitroulis (GR) Speakers J. Chorostowska-Wynimko (PL) D. Spyratos (GR) V. Skouras (GR) K. Samitas (GR)
This is the first event to sign the pledge to a series of congresses on a yearly basis focused on the latest developments and publications that are relevant to respiratory clinicians based on last year’s literature as well as on the recent clinically relevant guidelines on all therapeutic areas.
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Saturday 29 Aug 2020
Proposed guidance on the respiratory follow up of patients with #COVID-19 pneumonia in @ThoraxBMJ.
The COVID-19 pandemic has led to an unprecedented surge in hospitalised patients with viral pneumonia. The most severely affected patients are older men, individuals of black and Asian minority ethnicity and those with comorbidities. COVID-19 is also associated with an increased risk of hypercoagula...
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Saturday 29 Aug 2020
Ventilator Sharing during an Acute Shortage Caused by the COVID-19 Pandemic
To the Editor:Coronavirus disease (COVID-19) is a rapidly expanding global pandemic. In March 2020, models forecasted imminent exhaustion of regional ventilator supply in New York (1). In response, we developed a novel ventilator sharing strategy to support two patients simultaneously with one venti...
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Saturday 29 Aug 2020
Among children with persistent asthma and low vitamin D levels, vitamin D3 supplementation, compared with placebo, did not significantly improve the time to a severe asthma exacerbation. buff.ly/3jdjrlW
This randomized trial compares the effects of vitamin D3 vs placebo on time to severe exacerbation in children with asthma and low vitamin D levels.
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Saturday 29 Aug 2020
A new peer-reviewed study published in Science Advances confirms the success of a new #COVID-19 pooling test that identifies all positive subjects, including asymptomatic carriers, in a single round of testing.
A new peer-reviewed study published in Science Advances confirms the success of a new COVID-19 pooling test that identifies all positive subjects, including asymptomatic carriers, in a single round of testing.
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Saturday 29 Aug 2020
Stay safe and healthy during COVID-19 ⬇️
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Saturday 29 Aug 2020
What is New in Respiratory Medicine Ioannina 2020 #WiNRespMed https://bit.ly/2EPlUUA
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Friday 28 Aug 2020
Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19
A 38-year-old man presented with a 6-day history of gradually worsening cough and asthenia and secondary anosmia and agueusia. He had no prior personal medical history. His mother had a history of diabetes mellitus and his son was followed for haemophilia A. His spouse had exhibited similar symptoms...
