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Tuesday 25 Aug 2020
Is it time to standardize quantitative lung ultrasound? Read more POCUS first literature in journal CHEST®: https://hubs.ly/H0t__DH0
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Tuesday 25 Aug 2020
A new study published on the preprint server medRxiv* aims to explore the effects of treatment with ICS on the expression of specific genes related to SARS-CoV-2 infection in bronchial epithelial cells in a prospective interventional design.
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Tuesday 25 Aug 2020
This comprehensive literature review highlights the risk of exacerbations for patients with mild asthma buff.ly/3jdfs8U
Background Although most patients with asthma have mild disease, data on how mild asthma is defined, and how frequently exacerbations occur in this patient population are scarce, so we aimed to redress this. Methods We searched Medline and Medline In-Process (PubMed), and Embase in OVID for English-...
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Tuesday 25 Aug 2020
Bitter taste receptors are evolutionary conserved proteins that are likely part of a survival mechanism to sense and avoid potentially harmful food sources. A Paradigms and Perspectives piece discusses how they may also offer targets for asthma treatment.
Asthma is a chronic respiratory disease of high prevalence worldwide. Exaggerated airway smooth muscle (ASM) contraction, inflammation and remodeling of the airways, and airway hypersensitivity are key features that result in lumen narrowing and airflow obstruction, which cause wheezing, coughing, a...
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Tuesday 25 Aug 2020
Locations of Adolescent Physical Activity in an Urban Environment and their Associations with Air Pollution and Lung Function
Rationale: Physical activity while being exposed to high concentrations of air pollution may lead to greater inhalation of pollutant particles and gases. Thus, due to features of the built city env...
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Tuesday 25 Aug 2020
A novel rapid influenza diagnostic test demonstrated beneficial sensitivity and specificity for the detection of influenza A and B with positive user experience and no safety concerns, according to a study.
A novel rapid influenza diagnostic test demonstrated beneficial sensitivity and specificity for the detection of influenza A and B with positive user experience and no safety concerns, according to a study.“An easy home flu test has the potential to improve antiviral prescribing and reduce tra...
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Tuesday 25 Aug 2020
Electronic alert reduces excessive prescribing of short-acting #asthma relievers
An automatic, electronic alert on general practitioners' (GPs) computer screens can help to prevent excessive prescribing of short-acting asthma reliever medication, according to research presented at the 'virtual' European Respiratory Society International Congress.
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Tuesday 25 Aug 2020
COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 and differing COVID-19 disease phenotypes, with notable increased SARS-CoV-2 hospital presentations in patients with haematological cancers.
Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 infection and COVID-19 phenotypes. We generated individualised risk tables for patients with cancer, considering age, sex, and tumour subtype. Our results could be useful to assist physicians in informed ris...
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Monday 24 Aug 2020
Background Little is known about the impact of exacerbations on COPD progression or whether inhaled corticosteroid (ICS) use and blood eosinophil count (BEC) affect progression. We aimed to assess this in a prospective observational study. Methods The study population included patients with mild to....
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Sunday 23 Aug 2020
What can young people do for COVID19?
It is hard to put your life on hold, but we need young people's energy, to take control of our society and our future, which includes fighting COVID-19 - Dr Mike Ryan, WHO Emergencies Programme Executive Direcotr
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Saturday 22 Aug 2020
Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 - A Randomized Clinical Trial
Hospitalized patients with moderate COVID-19 randomized to a 5-day course of remdesivir had a statistically significantly better clinical status compared with those randomized to standard care at 11 days after initiation of treatment, but the difference was of uncertain clinical importance.
This open-label randomized trial compares the effect of remdesivir (5 or 10 days) vs standard care on clinical status 11 days after treatment initiation among patients with confirmed SARS-CoV-2 infection hospitalized with moderate pneumonia (room air oxygen saturation >94%).
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Saturday 22 Aug 2020
[IMG] "This type of mask does not prevent the person wearing the mask from transmitting COVID-19 to others," the CDC says. People should wear masks...
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Friday 21 Aug 2020
H επαναστατική αυτή θεραπεία για την κυστική ίνωση έλαβε έγκριση τον Οκτώβριο του 2019
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Friday 21 Aug 2020
This cohort study compares the excess deaths in New York City during the peak of the 1918 H1N1 influenza pandemic with those during the early period of the COVID-19 pandemic.
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Friday 21 Aug 2020
The sleep apnea-specific hypoxic burden predicts incident heart failure in men, irrespective of apnea-hypopnea index. Read more in journal CHEST®: https://hubs.ly/H0tH-6V0
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Friday 21 Aug 2020
Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study
The four dominant interrelated pathological processes in severe COVID-19 are diffuse alveolar damage, thrombosis, haemophagocytosis, and immune cell depletion. Additionally, several novel autopsy findings were reported including pancreatitis, pericarditis, adrenal micro-infarction, secondary disseminated mucormycosis, and brain microglial activation, which require additional investigation to understand their role in COVID-19.
Our series supports clinical data showing that the four dominant interrelated pathological processes in severe COVID-19 are diffuse alveolar damage, thrombosis, haemophagocytosis, and immune cell depletion. Additionally, we report here several novel autopsy findings including pancreatitis, pericardi...
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Thursday 20 Aug 2020
Correspondence from The New England Journal of Medicine — A SARS-CoV-2 mRNA Vaccine — Preliminary Report
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Thursday 20 Aug 2020
A single-dose intranasal ChAd vaccine protects upper and lower respiratory 2 tracts against SARS-CoV-2.
A single intranasal dose of ChAd-SARS-CoV-2-S 37 induces high levels of neutralizing antibodies, promotes systemic and mucosal IgA and T cell 38 responses, and virtually completely prevents SARS-CoV-2 infection in both the upper and lower 39 respiratory tracts. Intranasal administration of ChAd-SARS-CoV-2-S is a candidate for 40 preventing SARS-CoV-2 infection and transmission, and curtailing pandemic spread.
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Wednesday 19 Aug 2020
Surfaces and equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the emergency department at a university hospital
Surfaces and equipment contamination by SARS-CoV-2 RNA in an emergency department during the COVID-19 outbreak is low and concerns exclusively patients’ examination and monitoring rooms, preserving non-patient care areas.
Environmental contamination by patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through respiratory droplets suggests that s…
